Due to its tranquility and unspoiled natural beauty, Crestone has become home to a number of spiritual groups and retreat centers, representative of contemplative traditions from around the world.
- Manitou Foundation
- Academy of On
- Atalanta Association
- Buteyko Breathing Center
- Center for Contemplative Research
- Chamma Ling
- Crestone Baptist Church
- Crestone End of Life Project
- Crestone Mountain Zen Center
- Dharma Ocean Foundation
- Haidakhandi Universal Ashram
- Karma Thegsum Tashi Gomang
- Little Shepherd in the Hills Chapel
- Mangala Shri Bhuti
- Neighbors Helping Neighbors
- Pundarika Foundation
- Shakti Sharanam
- Sri Aurobindo Learning Center
- Shumei International Institute
- Vajra Vidya
- Way of Nature
- Wellness Institute
- White Jewel Mountain
- Yeshe Khorlo